Web21 Apr 2024 · Tfh cells are required for GC formation and maintenance 3, 4, 5, 6, 7, and Foxp3 + T follicular regulatory (Tfr) cells participate in the regulation of GC reactions 8, 9, 10, 11, 12. Lack of Tfr... WebFollicular helper T cells (also known as follicular B helper T cells and abbreviated as TFH ), are antigen -experienced CD4 + T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing ...
New insights into follicular helper T cell response and ... - Nature
Web22 Nov 2024 · CXCR5 + memory CD4 + T cells in human blood represent a circulating compartment of T follicular helper (Tfh) cells (termed circulating Tfh: cTfh cells). cTfh cells are composed of subsets that differ in phenotype and functions, and include resting and activated cell populations. Analysis of cTfh cell subsets have proven to be valuable to … the jiao group
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Web25 Feb 2024 · Tfh cells are a unique lineage of CD4 + T cells that express the master transcription factor B-cell lymphoma 6 (Bcl-6). They are phenotypically characterized by … Web18 Jun 2013 · Abstract. T follicular helper (Tfh) cells are the main T helper (Th) cell subset that provides help to B cells, supporting germinal center induction, affinity maturation, and generation of memory B cells and long … Web11 Jun 2024 · Objective To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) in a randomized, double-blind, placebo-controlled clinical trial. Methods A post hoc analysis was performed in a randomized cohort of SLE patients (n=60) receiving low-dose IL-2 therapy … the jhin